A POU-domain transcription factor in early stem cells and germ cells of themammalian embryo
摘要：
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
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关键词：
Endoderm Germ Cells Oocytes Transcription Factors DNA-Binding Proteins Nucleic Acid Hybridization Base Sequence Genes, Homeobox Cell Differentiation Gene Expression
DOI：
10.1016/0168-9525(90)90243-Y
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年份：
1990
Elsevier
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