Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes
申请(专利)号:
US19940220124
申请日期:
1994-03-30
公开/公告号:
US5466467A
公开/公告日期:
1995-11-14
申请(专利权)人:
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
关键词:
ENZYMES LIPIDS LIPOSOMES POLYMERIZATION PROTEINS PATENTS METALS CHEMICALS CHELATION COVALENT BONDS
被引量:
摘要:
The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub. 3).sub.3.
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