Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes

阅读量:

26

申请(专利)号:

US19940220124

申请日期:

1994-03-30

公开/公告号:

US5466467A

公开/公告日期:

1995-11-14

申请(专利权)人:

THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

发明人:

A Singh

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被引量:

66

摘要:

The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub. 3).sub.3.

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