Clonal Diseases of Large Granular Lymphocytes
摘要：
Three distinct clinical syndromes occur in patients with increased numbers of circulating LGL. Patients with T-LGL leukemia have clonal proliferations of CD3+ LGL typically associated with chronic neutropenia and autoimmune features. NK-LGL leukemia is characterized by clonal CD3- LGL proliferation with an acute clinical presentation marked by massive hepatosplenomegaly and systemic illness. However, most patients with increased numbers of CD3- LGL do not have clinical features of NK-LGL leukemia and have a chronic clinical course. X-linked gene analyses have supported a polyclonal LGL lymphocytosis in this syndrome. Further studies are needed to determine whether clonal progression can occur in these patients.
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关键词：
Humans Lymphocyte Subsets T-Lymphocytes Lymphoproliferative Disorders Leukocyte Count Leukemia, Prolymphocytic, T-Cell Killer Cells, Natural Middle Aged Antigens, CD3 Clone Cells
DOI：
http://dx.doi.org/
被引量：
年份：
1993
Elsevier
万方医学
dx.doi.org
BioMed Central
NCBI
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