Coactivator and corepressor complexes in nuclear receptor function.
摘要：
The nuclear hormone receptors constitute a large family of transcription factors. The binding of the hormonal ligands induces nuclear receptors to assume a configuration that leads to transcriptional activation. Recent studies of retinoic acid and thyroid hormone receptors revealed that, upon ligand binding, a histone deacetylase (HDAC)-containing complex is displaced from the nuclear receptor in exchange for a histone acetyltransferase (HAT)-containing complex. These observations suggest that ligand-dependent recruitment of chromatin-remodeling activity serves as a general mechanism underlying the switch of nuclear receptors from being transcriptionally repressive to being transcriptionally active.
展开
关键词：
Animals Histone Deacetylases DNA-Binding Proteins Saccharomyces cerevisiae Proteins Nuclear Proteins Receptors, Cytoplasmic and Nuclear Transcription Factors Repressor Proteins
DOI：
10.1016/S0959-437X(99)80021-5
被引量：
年份：
1999
Elsevier
万方医学
Semantic Scholar
Ingenta
dx.doi.org
查看更多
BioOne
Europe PMC
NCBI
NCBI
ResearchGate
EBSCO
ajpheart.physiology.org
mysciencework.com
www.socolar.com
pubfacts.com
hw-f5-embojnl.highwire.org
embor.embopress.org
charlie.ambra.unibo.it
(全网免费下载)
plantphysiol.org
molbiolcell.org
infona.pl
mendeley.com
readcube.com
deepdyve.com
jlr.org
scienceopen.com
charlie.ambra.unibo.it
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
