Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study

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阅读量：

211

作者：

M Krssak，KF Petersen，A Dresner，L Dipietro，SM Vogel，DL Rothman，GI Shulman，M Roden

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摘要：

Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance ( 1 H NMR) spectroscopy technique, which enables non-invasive and rapid ( 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults ( n = 23, age 29 ± 2 years, BMI = 24.1 ± 0.5 kg/m 2 ) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic ( 450 pmol/l)-euglycaemic ( 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1 H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation ( r = –0.692, p = 0.0017) between intramyocellular lipid content and M-value (100–120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value ( r = –0.54, p = 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1 H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans. [Diabetologia (1999) 42: 113–116]

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关键词：

Keywords Intramyocellular lipids insulin sensitivity NMR spectroscopy skeletal muscle triglycerides

DOI：

10.1007/s001250051123

被引量：

3821

年份：

1999