Synthesis of 3‐substituted‐4‐phenyl‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydrobenzo[4,5]thieno[2,3‐á]pyrimidines
摘要：
The reactions between 3-benzoyl-2-isothiocyanato-4,5,6,7-tetrahydrobenzo[ b ]thiophene and hydrazine or primary amines have been studied. The products obtained were identified as derivatives of 4-phenyl-2-thioxo-2,3,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3- d ]pyrimidine. Their easy reduction with sodium borohydride provided a useful method for the synthesis of 3-substituted-4-phenyl-2-thioxo-1,2,3,4,5,6,7,8-octahydrobenzo[4,5]thieno[2,3- d ]pyrimidines. Both kind of compounds were evaluated as potential analgesic, anti-inflammatory and anti-arthritic agents.
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DOI：
10.1002/jhet.5570270229
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年份：
1990
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来源期刊
Journal of Heterocyclic Chemistry
1990/02/01
引用走势
2010
被引量：20
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