Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
摘要：
Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly reduced mammary gland development after their first, but not subsequent, pregnancies. Homozygous females were sterile owing to a complete failure of embryonic implantation. Moreover, they presented multiple reproductive abnormalities, including irregular cycles, reduced fertilization rates, defective preimplantation embryonic development, and lack of pseudopregnancy. Half of the homozygous males were infertile or showed reduced fertility. This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolactin receptor and its ligands.
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关键词：
Mammary Glands, Animal Animals Mice, Inbred C57BL Mice, Inbred CBA Mice Infertility, Male Infertility, Female Receptors, Prolactin Cloning, Molecular Gene Targeting
DOI：
10.1101/gad.11.2.167
被引量：
年份：
1997
Taylor & Francis
万方医学
dx.doi.org
NCBI
NCBI
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