Growth Hormone-Releasing Factor from a Human Pancreatic Tumor that Caused Acromegaly

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作者：

R.P GUILLEMIN，P Brazeau，P. E. Bhlen，F. S. Esch，WB Wehrenberg

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摘要：

A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-A la-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu- Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH$_{2}$. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physicochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.

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关键词：

Humans Pancreatic Neoplasms Acromegaly Hormones, Ectopic Biological Assay Amino Acid Sequence Growth Hormone-Releasing Hormone

DOI：

10.1126/science.6812220

被引量：

2461

年份：

1982