Inhibition of histidine decarboxylase. Derivatives of histidine
摘要：
Twenty-eight derivatives of histidine were tested as inhibitors of histidine decarboxylase from rat stomach. Potent inhibition was observed with the methyl ester of L-histidine (1) which had a Ki = 1.8 X 10(-6) M. Substitution on 1 at various positions resulted in a decrease or complete loss of inhibition. Substituent requirements for inhibition of histidine decarboxylase are discussed. A simple disposable apparatus for the radiometric assay of histidine decarboxylase is described.
展开
关键词：
Animals Rats Stomach Carboxy-Lyases Histidine Decarboxylase Kinetics Histidine Structure-Activity Relationship Male
DOI：
10.1021/jm00214a009
被引量：
年份：
1977
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
