Enantiomer Separation of _ Blocking Drugs by High Performance Liquid as Chiral Stationary Phase

来自 知网

阅读量:

15

作者:

Y ZhangX ZouZ Yun

展开

摘要:

Direct separation of racemic atenolol using normal _ phase HPLC with amide derivative as chiral stationary phase has been investigated. The effect of different content of 1,2 _ dichloroethane and methanol in mobile phase on the chiral separation was discussed. The effect of organic regulators on resolution was also studied. The optimized mobile phase for racemic atenolol is V(n _ hexane)V(1,2 _ dichloroethane)V(methanol) =68266. The resolution results of atenolol, propranolol and celiprolol were compared and the mechanisms of chiral separation were discussed.

展开

被引量:

4

年份:

1999

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用