Suspending an active ingredient in a cationic copolymer dispersion, salt-formation and pelletization by dropping the dispersion into an aqueous anionic polymer solution, separating and drying the pellets; time-release drug delivery for vaginal use, implant
公开/公告号:
US20040247687 A1
公开/公告日期:
2004年12月9日
被引量:
摘要:
The invention relates to a method for the production of active ingredient-containing pellets by the steps of a) suspending or dissolving a pharmaceutical active ingredient in a dispersion, which contains a cationic copolymer, b) dropping said dispersion, containing the pharmaceutical active ingredient and the copolymer in an aqueous polymer solution, which contains an anionic copolymer, incompatible with the cationic copolymer, so that active ingredient-containing pellets precipitate and c) separating said active ingredient-containing pellets from the aqueous polymer solution and then drying said pellets. The invention also relates to said pellets and the use thereof in diagnostics or cosmetics, as well as pharmaceutical forms which contain said pellets.
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