Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst

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61

作者:

H BoH WeiRX ZhenPD Xiao

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摘要:

The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thiourea-guanidine bifunctional organocatalyst. The novel transformations exhibited high diastereoselectivities, and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities (up to 88% ee).

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DOI:

10.1016/j.cclet.2011.01.038

被引量:

28

年份:

2011

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