摘要：

Until 1980, the two major classes of antidepressant drugs were the tricyclics (TCAs) and the monoamine oxidase inhibitors (MAOIs). During the 1980s several additional classes of drugs appeared. Among these, selective serotonin reuptake inhibitors (SSRIs) have a distinct and well-characterized mechanism of action, and have become among the most widely prescribed antidepressant drugs.

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