Increased Human Immunodeficiency Virus Loads in Active Methamphetamine Users Are Explained by Reduced Effectiveness of Antiretroviral Therapy

来自 EBSCO

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作者：

RJ Ellis，ME Childers，C Mariana，L Deborah，L Scott，the HIV Neurobehavioral Research Center Group

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摘要：

Abuse of methamphetamine (METH) is a frequent comorbidity among individuals infected with human immunodeficiency virus (HIV) type 1. In cell cultures and animal models, METH accelerates retroviral replication. To determine whether METH increases HIV replication in humans, we evaluated HIV loads in HIV-positive METH users and nonusers. We studied 3 groups: Tox active METH use and positive urine toxicology results; METHTox , previous METH dependence/abuse and negative urine toxicology results; METHTox, no METH dependence/abuse and negative urine toxicology results. Tox subjects' plasma virus loads were significantly higher than METHTox and METHTox subjects'; cerebrospinal fluid virus loads showed a similar but nonsignificant trend. Stratification by use of highly active antiretroviral therapy (HAART) revealed that virus loads were higher only in those Tox subjects who reported receiving HAART. In contrast, abstinent former METH abusers (METHTox) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations.

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关键词：

Humans HIV-1 HIV Seropositivity Substance Abuse, Intravenous Methamphetamine RNA, Viral Central Nervous System Stimulants Anti-HIV Agents Antiretroviral Therapy, Highly Active Viral Load