Variant TREM2 as Risk Factor for Alzheimer's Disease
摘要：
Current knowledge about the pathogenic mechanism of Alzheimer's disease is based mainly on rare, high-penetrance variants in genes encoding amyloid precursor protein, presenilin 1, and presenilin 2, which result in familial early-onset Alzheimer's disease. However, Alzheimer's disease is predominantly a sporadic late-onset disease with exponentially increasing prevalence starting at the age of 65 years. Genomewide association studies have recently identified several risk variants for late-onset Alzheimer's disease, but aside from the well-known ε4 allele of apolipoprotein E, these variants are generally associated with very low risk; in addition, such variants are noncoding and more challenging to link to molecular function. ...
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DOI：
10.1056/NEJMe1213157
被引量：
年份：
2013
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