Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints

BackgroundTools to explore large compound databases in search for analogs of query molecules provide a strategically important support in drug discovery to...

M Awale，X Jin，Reymond, Jean-Louis - 《Journal of Cheminformatics》

Stereoselective Interaction Between Tetrahydropalmatine Enantiomers and CYP Enzymes in Human Liver Microsomes

Tetrahydropalmatine (THP), with one chiral center, is an alkaloid that possesses analgesic and many other pharmacological actives. The aim of the present s...

Si-Yuan，Sun，Yu-Qing，... - 《Chirality》

Stereoselective electron transfer between chiral substrates and metal chelates anchored to polypeptides.

Electron transfer from ortho-dihydroxy substrates, such as L(+)-ascorbic acid, L-adrenaline, and L-dopa, to iron(III) in [Fe(tetpy)(OH)2]+ ions anchored to...

B Pispisa，A Palleschi，G Paradossi - 《Biopolymers》

Agrochemicals Take a Turn Into Chirality

Chirality has become a hot topic in pharmaceuticals, but it is also gaining importance in agrochemicals. For though the two markets are very different, advances in stereoselective synthesis and the potential for increased activity, reduc...

CMR Group - 《Chemical Market Reporter》

Stereoselective synthesis of phosphorous containing actives

Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically a...

BS Ross，SM Joseph，PG Reddy

Efficient and Stereoselective Synthesis of New 5-Aryl Prolines via Heck Arylation

The exceptional conformational rigidity conferred on proline by its cyclic system has been the keystone for the control of tridimensional structure of pept...

Santos，R M.，N M.，...

STEREOSELECTIVE METHOD OF PRODUCING 6α-FLUOROPREGNANES AND INTERMEDIARIES

The invention relates to 6α-fluoropregnanes (I), wherein: the line of points between positions 1 and 2 represents a single or double bond; R1 denotes OH, OCOR2, X, SO3R3 or a (R7)(R8)(R9)SiO-group, wherein X is halogen, R2 and R3 denote...

GJV Murillo，GLO Silva，JJ Martín - WO