Enantioselective reformatsky reaction induced by chiral β-amino alcohols
摘要：
Reformatsky reagent derived from tert-butyl α-bromoacetate adds to carbonyl compounds in the presence of chiral amino alcohols leading to β-hydroxy tert-butyl esters with good e.e. The enantioface differentiation depends on the reaction conditions and on the structure of the chiral auxiliary. The best chemical yields and e.e. are obtained for aromatic aldehydes by using the C-2 symmetrical chiral bis-amino alcohol ( 5 ) derived from m-xylylene diamine.
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DOI：
10.1016/S0040-4020(97)00099-9
被引量：
年份：
1997
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来源期刊
Tetrahedron
10 March 1997
引用走势
2012
被引量：31
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