Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction.
摘要：
Our data suggest a high oxidative stress due to the release of nitric oxide synthase and xanthine oxidase within the dilated spermatic vein. This reaction resulted in dramatic formation of nitric oxide, peroxynitrite and S-nitrosothiols, which are biologically active. Formation of peroxynitrite from the reaction of nitric oxide with superoxide could be a causative factor for impaired sperm function in patients with varicocele.
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关键词：
Humans Penis Spermatozoa Veins Varicocele Nitrates Sulfhydryl Compounds Oxidation-Reduction Xanthine Oxidase Infertility, Male
DOI：
10.1016/S0022-5347(01)65403-X
被引量：
年份：
1996
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