Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles.
摘要：
The asymmetric Mannich reaction of 3-substituted oxindoles and N-Boc imines was investigated for the first time, employing bifunctional thiourea-tertiary amine organocatalysts based on DPEN scaffold. The novel transformations exhibited high diastereoselectivities, and the Mannich adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in good to excellent enantioselectivities (up to 95% ee).
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DOI：
10.1021/ol801351j
被引量：
年份：
2008
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来源期刊
Organic Letters
2008/08/21
引用走势
2010
被引量：61
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