Excavatolides F-M, new briarane diterpenes from the gorgonian Briareum excavatum
摘要:
A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U-Z (1-6). The structures and relative stereochemistry of metabolites 1-6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.
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关键词:
low molecular weight thaumatin-like protein antifungal activity pathogenesis-related protein winter rye Secale cereale
DOI:
10.1021/np980446h
被引量:
年份:
1999












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