Excavatolides F-M, new briarane diterpenes from the gorgonian Briareum excavatum

作者:

PJ SungJH SuCY DuhMY ChiangJH Sheu

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摘要:

A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U-Z (1-6). The structures and relative stereochemistry of metabolites 1-6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.

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DOI:

10.1021/np980446h

被引量:

316

年份:

1999

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来源期刊

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2007
被引量:42

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