A General Catalyst for the Asymmetric Strecker Reaction

来自 Wiley

阅读量:

25

作者:

MS SigmanPV AndEN Jacobsen

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摘要:

3.0.CO;2-U/asset/image_m/mcontent.xxx?v=1&s=09d87c53fa2e5ba330e7818e35fbaa0066bcd616" class="figZoom" shape="rect">From a parallel library of 70 compounds, the salicylidene imine derivative 1 was identified as a remarkably enantioselective and general catalyst for the Strecker reaction with a variety of aromatic and aliphatic aldimines. While the soluble catalyst affords slightly higher ee values in most reactions, the use of its polystyrene-resin-bound analogue allows facile isolation of the Strecker products in nearly quantitative yield, and it can be recycled over ten times without loss of activity or selectivity.

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DOI:

10.1002/(SICI)1521-3773(20000403)39:7<1279::AID-ANIE1279>3

被引量:

877

年份:

2000

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2006
被引量:136

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