Inflammatory bowel disease: cause and immunobiology

来自万方

喜欢 0

阅读量：

561

作者：

Dr Daniel C Baumgart MD a，Prof Simon R Carding PhD b

展开

摘要：

Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation and hygiene), infectious microbes, ethnic origin, genetic susceptibility, and a dysregulated immune system can result in mucosal inflammation. After describing the symbiotic interaction of the commensal microbiota with the host, oral tolerance, epithelial barrier function, antigen recognition, and immunoregulation by the innate and adaptive immune system, we examine the initiating and perpetuating events of mucosal inflammation. We pay special attention to pattern-recognition receptors, such as toll-like receptors and nucleotide-binding-oligomerisation-domains (NOD), NOD-like receptors and their mutual interaction on epithelial cells and antigen-presenting cells. We also discuss the important role of dendritic cells in directing tolerance and immunity by modulation of subpopulations of effector T cells, regulatory T cells, Th17 cells, natural killer T cells, natural killer cells, and monocyte-macrophages in mucosal inflammation. Implications for novel therapies, which are discussed in detail in the second paper in this Series, are covered briefly.

展开

关键词：

Environmental Exposure Genetic Predisposition to Disease Immune System 环境暴露疾病遗传易感性免疫系统炎性肠疾病

DOI：

10.1016/S0140-6736(07)60750-8

被引量：

1102

年份：

2015