摘要：

To determine whether the route and/or composition of nutritional support alters intestinal barrier function (measured as bacterial translocation), were divided into three groups: food (controls), intravenous total parenteral nutrition (IV-) fed, and oral total parenteral nutrition (ORAL-) fed. Bacterial translocation did not occur in the that were fed normally, but did occur in 60% of the fed the IV-or the ORAL-diets for 7 days (p less than 0.05). Since both the IV-and ORAL-diets induced bacterial translocation and the solution (28% and 4.5% amino acids) lacks fiber, two additional groups of were fed orally 2.5 gm cellulose powder/day plus solution by either the intravenous or the oral route. The addition of cellulose powder decreased the incidence of bacterial translocation to 8% in the group fed the ORAL-diet and to 0% in the group fed the IV-diet. Cellulose improved intestinal barrier function, even though it did not prevent bacterial overgrowth or the loss of mucosal mass in the fed the IV-or ORAL-diets. Cellulose powder appears to have prevented bacterial translocation primarily by preventing IV-- or ORAL--induced alterations in mucosal structure. Thus the oral administration of this fiber maintains intestinal barrier function and prevents bacterial translocation even in the absence of oral nutrients.

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