Intrathecal morphine in mice: A new technique

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阅读量:

193

作者:

JLK HyldenGL Wilcox

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摘要:

A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [ 3 H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

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DOI:

10.1016/0014-2999(80)90515-4

被引量:

2765

年份:

1980

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来源期刊

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2010
被引量:201

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