摘要：

The general solvation equation log L = c + rR 2 + s + a + b + l log L 16 has been used to analyze the solubility of solute gases and vapors, as log L values, in water, blood, and a variety of other biological fluids and tissues. The explanatory variables are R 2, the solute excess molar refraction; , the solute dipolarity/polarizability; 2H and 2H the solute hydrogen-bond acidity and basicity; and log L 16, where L 16 is the solute Ostwald solubility coefficient of hexadecane. The obtained coefficients then serve to characterize the biological phase as follows: r + s is the phase dipolarity/polarizability, a is the phase hydrogen-bond basicity, b is the phase hydrogen-bond acidity, and l is the phase lipophilicity. In addition to characterization of phases, the equation can be used to determine quantitatively solute/phase interactions and predict further log L values. A similar equation in which McGowan's characteristic volume, V x, replaces the log L 16 descriptor can be used to analyze partitions between phases. For example, water/phase and blood/phase partition coefficients are analyzed, and the analysis leads again to coefficients that characterize phases and to the prediction of partition coefficients.

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