Human D-type cyclin.
摘要：
A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN -type cyclins, but appears to define a new subclass within the cyclin gene family. Transcription of the cyclin D1 gene gives rise to two major transcripts through alternative polyadenylation. The cyclin D1 gene transcript and its 34 kd product are both abundant in the glioblastoma cell line of origin.
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关键词：
Humans Cell Line Hela Cells Saccharomyces cerevisiae Glioma DNA, Neoplasm RNA, Neoplasm Cyclins Cloning, Molecular Blotting, Western
DOI：
10.1016/0092-8674(91)90100-D
被引量：
年份：
1991
Elsevier
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Elsevier
万方医学
Semantic Scholar
Europe PMC
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