Polo-like kinases and the orchestration of cell division.
摘要：
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular structures through interactions with phosphorylated docking proteins. Moreover, information is emerging on the substrate specificity of Plks and the role of individual substrates in M-phase progression.
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关键词：
Humans Amphotericin B Aged Lung Diseases, Fungal Thrombocythemia, Essential Pneumonia Mitosporic Fungi Female
DOI：
10.1038/nrm1401
被引量：
年份：
2004
Nature
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Nature
Springer
EBSCO
万方医学
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