Mitochondria as the central control point of apoptosis.
摘要：
Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and coordinate caspase activation through the release of cytochrome c as a result of the outer mitochondrial membrane becoming permeable. The mechanisms that lead to this permeability are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event.
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关键词：
Mitochondrion Apoptosis Cell death Capase Kinesin Bax Bcl-2 Membrane structure Cytochrome c Permeability transition pore (PTP
DOI：
10.1016/S0962-8924(00)01803-1
被引量：
年份：
2000
Elsevier
Taylor & Francis
万方医学
掌桥科研
Ingenta
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