Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
摘要：
The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular smooth muscle cells, glia and neurons. The NVU controls blood-brain barrier (BBB) permeability and cerebral blood flow, and maintains the chemical composition of the neuronal 'milieu', which is required for proper functioning of neuronal circuits. Recent evidence indicates that BBB dysfunction is associated with the accumulation of several vasculotoxic and neurotoxic molecules within brain parenchyma, a reduction in cerebral blood flow, and hypoxia. Together, these vascular-derived insults might initiate and/or contribute to neuronal degeneration. This article examines mechanisms of BBB dysfunction in neurodegenerative disorders, notably Alzheimer's disease, and highlights therapeutic opportunities relating to these neurovascular deficits.
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关键词：
Animals Humans Endothelium Blood-Testis Barrier Pericytes Myocytes, Smooth Muscle Alzheimer Disease Neurodegenerative Diseases Biological Transport Cerebrovascular Circulation
DOI：
10.1038/nrn3114
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BMJ
Springer
Nature
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