The histidine protein kinase superfamily.
摘要：
Signal transduction in microorganisms and plants is often mediated by His-Asp phosphorelay systems. Two conserved families of proteins are centrally involved: histidine protein kinases and phospho-aspartyl response regulators. The kinases generally function in association with sensory elements that regulate their activities in response to environmental signals. A sequence analysis with 348 histidine kinase domains reveals that this family consists of distinct subgroups. A comparative sequence analysis with 298 available receiver domain sequences of cognate response regulators demonstrates a significant correlation between kinase and regulator subfamilies. These findings suggest that different subclasses of His-Asp phosphorelay systems have evolved independently of one another.
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关键词：
Bacteria Archaea Protein Kinases Evolution, Molecular Signal Transduction Amino Acid Sequence Sequence Homology, Amino Acid Molecular Sequence Data
DOI：
10.1016/S0065-2911(08)60167-8
被引量：
年份：
1999
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