Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.
摘要：
Hybrid human — mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5′ part of the mouse Thy-1.1 gene combined with the 3′ human untranslated regions was expressed abnormally in the kidney podocytes, which resulted in severe proteinuria and subsequent death in several founder mice. A hybrid Thy-1 gene composed of the human coding region with the 5′ and 3′ flanking regions of the mouse gene was expressed abnormally in a different part of the kidney (the tubular epithelia), which resulted in a proliferative kidney disorder. In addition, a neoplasm was found in the brain of one of these mice. These results show that the Thy-1 protein can play an important role in the activation, proliferation, and differentiation of many different cell types.
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DOI：
10.1016/0092-8674(87)90006-7
被引量：
年份：
1988
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