摘要：

New 7-chloro-4-phenoxyquinoline derivatives bearing formyl, oxime and thiosemicarbazone functional groups were easily prepared using 4,7-dichloroquinoline and functionalized phenols as inexpensive and commercially available starting materials. Their chemical structures were confirmed by use of infrared and H, C nuclear magnetic resonance experiments. All the synthesized compounds were evaluated for their cytotoxicity against the cell lines MCF-7, SKBR-3, PC3, HeLa and human dermis fibroblast as non-tumor cells, in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) for assay. The quinoline derivatives 3a and 3d resulted as promising models for antitumor drugs, displaying good cytotoxic activity against four human cancer cell lines (9.18 M < IC50 < 50.75 M). The phenoxyquinoline 3d stands out by its low unspecific cytotoxicity and high selectivity on tumor lines SKBR-3, HeLa and PC3 cells.

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