"Designer Acids": Combined Acid Catalysis for Asymmetric Synthesis

来自 EBSCO

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摘要：

Lewis and Br?nsted acids can be utilized as more-effective tools for chemical reactions by sophisticated engineering (designer acids). The ultimate goal of such designer acids is to form a combination of acids with higher reactivity, selectivity, and versatility than the individual acid catalysts. One possible way to take advantage of such abilities may be to apply a combined acids system to the catalyst design. The concept of combined acids, which can be classified into Br?nsted acid assisted Lewis acid (BLA), Lewis acid assisted Lewis acid (LLA), Lewis acid assisted Br?nsted acid (LBA), and Br?nsted acid assisted Br?nsted acid (BBA), can be a particularly useful tool for the design of asymmetric catalysis, because combining such acids will bring out their inherent reactivity by associative interaction, and also provide more-organized structures that allow an effective asymmetric environment.

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关键词：

asymmetric catalysis Brønsted acids catalysis design cooperative effects Lewis acids

DOI：

10.1002/anie.200460394

被引量：

907

年份：

2005