A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery
摘要：
A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.
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关键词：
pyridine derivatives diastereoselective syntheses, enantioselective syntheses (incl. ci/trans‐isomerism) reduction, hydrogenation
DOI：
10.1002/chin.200114151
被引量：
年份：
2000
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来源期刊
Organic Letters
2000年
引用走势
2010
被引量：59
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