Effects of cycloheximide on delayed neuronal death in rat hippocampus

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作者：

K Goto，A Ishige，K Sekiguchi，S Iizuka，A Sugimoto，M Yuzurihara，M Aburada，E Hosoya，K Kogure

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摘要：

The effect of cycloheximide, a protein synthesis inhibitor, on hippocampal selective neuronal death was morphologically studied in rats subjected to 10 min forebrain ischemia using a 4-vessel occlusion model. Neuronal damage in the hippocampal CA1 subfield 72 h after ischemic insult was dramatically decreased by the lasting inhibition of protein synthesis through consecutive administration of cycloheximide. Cycloheximide, which was administered once within the first 24 h of recirculation, showed protective action on ischemic cell necrosis and its most potent effect was observed when injected at 12 h of post-ischemia. After 36 h of recirculation, however, treatment with cycloheximide could no longer prevent cell death. The possibility is considered that hippocampal delayed neuronal death following transient ischemia is caused by abnormal protein(s).

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关键词：

Cerebral ischemia Hippocampus Selective vulnerability Delayed neuronal death Protein synthesis Cycloheximide Rat

DOI：

10.1016/0006-8993(90)90144-Z

被引量：

425

年份：

1990