Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
摘要：
Immune cells take residence in metabolic tissues, providing a framework for direct regulation of nutrient metabolism. Despite conservation of this anatomic relationship through evolution, the signals and mechanisms by which the immune system regulates nutrient homeostasis and insulin action remain poorly understood. Here, we demonstrate that the IL-4/STAT6 immune axis, a key pathway in...
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关键词：
Animals Mice, Inbred BALB C Mice, Knockout Mice Adipose Tissue Macrophages Leishmania major Cell Line Leishmaniasis, Cutaneous Insulin Resistance
DOI：
10.1038/nature05894
被引量：
年份：
2007
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