New Strategy for the Total Synthesis of Macrosphelides A and B Based on Ring-Closing Metathesis

New strategy for the total synthesis of macrosphelides A and B based on ring-closing metathesis - Matsuya, Kawaguchi, et al. - 2011 () Citation ...

Y Matsuya，T Kawaguchi，H Nemoto - 《Cheminform》

Total synthesis of macrosphelides A, B, and E: first application of ring-closing metathesis for macrosphelide synthesis.

A new synthetic route for macrosphelides A, B, and E based on ring-closing metathesis (RCM) was established. The substrates for RCM could be synthesized st...

T Kawaguchi，N Funamori，Y Matsuya，... - 《Journal of Organic Chemistry》

RCM mediated synthesis of macrosphelides I and G

and ring-closing metathesis strategies were used for the construction of the lactone ring.Graphical abstractRCM mediated synthesis of macrosphelides I and G...

GVM Sharma，KV Babu - 《Tetrahedron Asymmetry》

87(P-10) Total Synthesis of Macrosphelides Belonging to Bioactive Natural Macrolide Family

various oxidative derivatization of Macrosphelide Core (1) and a new synthetic route for macrosphelides A and B based on ring-closing metathesis. The...

Y Matsuya，T Kawaguchi，H Nemoto - 《Symposium on the Chemistry of Natural Products Symposium Papers》

Studies toward the Total Synthesis of Biselides & Radical Fluorination of Aliphatic Compounds

A proposed total synthesis of biselide A involves the cyclization of chloropolyols to form the substituted tetrahydrofuran and metathesis for construction of the (Z,Z)-1,4-diene. Specifically, direct ring-closing metathesis (RCM), relay...

H Fan

DIHYDROAZAMACROSPHELIDES : SYNTHESIS AND APOPTOSIS INDUCING ACTIVITIES

Dihydroazamacrosphelides, which were aza-analogues of 3-epi macrosphelide L, were prepared according to ring-closing metathesis strategy. Their biological ...

Y Matsuya，Y Kobayashi，T Kondo，... - 《Heterocycles》

Studies Toward the Total Synthesis of Biselide A

The use of natural products for medicinal purposes is a tradition dating back to ancient times. To this day bioactive natural products continue to inspire a large proportion of the new pharmaceuticals that are developed each year. Many n...

MW Taron - 《Chemical Science》

Total Synthesis of Macrosphelides

Total syntheses of macrosphelides published up to August, 2004 are described in the following order : (1) lactonization at the three possible ester linkage...

Yuichi，Kobayashi - 《Journal of Synthetic Organic Chemistry Japan》

Design, Synthesis, and Biological Evaluation of Artificial Macrosphelides in the Search for New Apoptosis-Inducing Agents

Various artificial macrosphelides were designed and synthesized, including ring-enlarged analogues and epothilone-hybrid compounds. Syntheses were accompli...

Y Matsuya，Y Kobayashi，T Kawaguchi，...

Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property.

Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using...

Y Matsuya，T Kawaguchi，K Ishihara，... - 《Organic Letters》