摘要：

The side-effect profiles of antidepressants are related to their acute mechanisms of action. TCAs lack specificity of their pharmacological action, and are associated with antimuscarinic, antihistaminic, and alpha-adrenergic blocking actions, that account for many unwanted side effects but do not contribute to their therapeutic profile. The SSRIs, as a result of their selective action to inhibit serotonin reuptake, appear to have more tolerable side effects than TCAs and are less likely to be lethal when taken in overdose. SSRIs have little or no affinity for neurotransmitter receptors. The most common side effect is gastrointestinal discomfort. Depression 2:119-126 (1994/1995). 1995 Wiley-Liss, Inc.

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