Apoptosomes: engines for caspase activation.
摘要：
Activation of the caspases that initiate apoptosis typically requires cognate scaffold proteins, including CED-4 in , derived from damaged mitochondria. Although Dark also has a WD40 region, its activation does not seem to involve cytochrome . CED-4 is essential for apoptosis in the worm and Dark for many apoptotic responses in the fly, but the Apaf-1/caspase-9 system probably amplifies rather than initiates the mammalian caspase cascade.
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DOI：
10.1016/S0955-0674(02)00381-2
被引量：
年份：
2002
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