Lucigenin (bis-N-methylacridinium) as a mediator of superoxide anion production.
摘要：
Lucigenin (bis-N-methylacridinium) (Luc2+) has frequently been used for the luminescent detection of O2-. In fact, the pathway leading to this luminescence requires univalent reduction of Luc2+ to LucH.+ followed by formation of an unstable dioxetane by reaction of LucH.+ with O2-. It is now shown that LucH.+ rapidly autooxidizes and so produces O2-. Luc2+ can thus mediate O2- production in systems, such as glucose plus glucose oxidase, in which there is ordinarily no O2- production. Luc2+ luminescence can thus be used as the basis for assaying superoxide dismutase activity but should not be used for measuring, or even detecting, O2-.
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关键词：
VANADATE-STIMULATED OXIDATION DEPENDENT CHEMI-LUMINESCENCE PERFUSED-RAT-LIVER LIPOAMIDE DEHYDROGENASE NITROBLUE TETRAZOLIUM ISCHEMIA-REPERFUSION BIOLOGICAL-MEMBRANES LUMINOL NAD(P)H CHEMILUMINESCENCE
DOI：
10.1006/abbi.1997.9766
被引量：
年份：
1997
Taylor & Francis
Elsevier
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