Metalloproteinases and their inhibitors—diagnostic and therapeutic opportunities in orthopedics
摘要：
Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.
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关键词：
Anisomelia (LLI/LLD Bifocal osteotomy Callotasis (callus taxis = callus distraction Congenital Pseudarthrosis of the Tibia (CPT Complications Deformity Distraction Osteogenesis (DO Ilizarov (method/External Fixator, IEF IntraMedullary nail (IM nail Leg/Limb Length Discrepancy (LLD
DOI：
10.3109/17453670903448257
被引量：
年份：
2009
Taylor & Francis
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