Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
摘要:
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
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关键词:
Macrophages Embryo, Nonmammalian Animals Drosophila Escherichia coli Staphylococcus aureus Carrier Proteins Ion Pumps Antigens, CD36 Drosophila Proteins
DOI:
10.1126/science.284.5422.1991
被引量:
年份:
1999




































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