The broad-spectrum antiviral functions of IFIT and IFITM proteins
摘要：
Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families - the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
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关键词：
INTERFERON-STIMULATED GENES INDUCIBLE TRANSMEMBRANE PROTEINS VIRUS-RNA REPLICATION DOUBLE-STRANDED-RNA WEST NILE VIRUS MESSENGER-RNA TRANSLATION INITIATION S-PALMITOYLATION DNA-REPLICATION
DOI：
10.1038/nri3344
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年份：
2013
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