摘要：

Previous work in this laboratory (Gholson and Henderson 1958) has shown that a major portion of a test dose of DL-tryptophan-7a-C 14 is metabolized by the rat to C 14O 2 via acetate-1-C 14, 3-hydroxyanthranilic acid-2-C 14 (3-OHAA) being a probable intermediate (Gholson and Henderson 1959). Consideration of possible metabolic sequences between 3-OHAA-2-C 14 and acetate-1-C 14 suggested some five-carbon dicarboxylic acids as plausible intermediates. A number of these compounds have been tested by the "metabolite overloading" technique (Rothstein and Miller 1954a) in the rat with tryptophan-7a-C 14 and 3-OHAA-H 3. Isotopes from both of these compounds were incorporated into excreted glutaric acid, but not into any other compound so far tested by this technique.

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