摘要：

A causal link between persistent activation of a lymphoid compartment and the occurrence of lymphoma is bestestablished in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type. The contribution of such factors T-cell neoplasia is unclear, although immunophenotypicattributes of T-cell large granular lymphocytic leukemia (T-LCL) indicate that this disease is derived fromantigen-stimulated cytotoxic T cells. These attributes include the expression of natural killer (NK) -cell-associated receptors (NKRs), a group of proteins broadly divided into the CD94/NKG2heterodimer and the killer cell immunoglobulin-like receptor (KIR) types that are normally present on NK-cells and a subset of memory cytotoxic T cells. Non-hepatosplenic gamma delta T-celllymphomas are another group of cytotoxic T-cell malignancies that have been associated with chronic antigen exposure. The role of antigenic stimulation in the etiology of hepatosplenic T-cell lymphoma (HSTCL), a disorder of cytotoxic T cells that is frequently, but not exclusively, of gamma delta lineage, is unclear. There have been few studies of the NKR expression in this disease. Given the possible contribution of antigenic stimulation to the development of cytotoxic T-cell malignancies, we examined NKR expression in a group of seven HSTCL cases.

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