The influence of hepatitis B virus on antiviral treatment with interferon and ribavirin in Asian patients with hepatitis C virus/hepatitis B virus coinfection: a meta-analysis

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117

作者：

JY Liu，YJ Sheng，HD Hu，Q Zhong，R Hong

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摘要：

p pBackground/p pClinical and laboratory studies have indicated that coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) can suppress one another, eliciting a dominant disease phenotype. To assess whether HBV can influence the antiviral effect of treatment on HCV, we performed a meta-analysis to comparatively analyze the response to interferon plus ribavirin treatment in patients with HBV/HCV coinfection and HCV mono-infection./p pMethods/p pPublished studies in the English-language medical literature that involved cohorts of HBV/HCV coinfection and HCV mono-infection were obtained by searching Medline, Cochrane and Embase databases. Studies that compared the efficacy of treatment with interferon plus ribavirin in HBV/HCV coinfection and HCV mono-infection were assessed. End-of-treatment virological response (ETVR), sustained virological response (SVR), HCV relapse rate, and alanine aminotransferase (ALT) normalization rate were compared between HBV/HCV coinfection and HCV mono-infection patients./p pResults/p pFive trials involving 705 patients were analyzed. At the end of follow-up serum ALT normalization rates in patients with HCV mono-infection were significantly higher than in patients with HBV/HCV coinfection (odds ratio (OR)=0.56, 95% confidence interval (CI): 0.40–0.80, itP/it=0.001). The ETVR and SVR achieved in HBV/HCV coinfection patients were comparable to those in HCV mono-infection patients (OR=1.03, 95% CI: 0.37–2.82, itP/it=0.96 and OR=0.87, 95% CI: 0.62–1.21, itP/it=0.38, respectively). The rate of relapse for HCV or HCV genotype 1 was not significantly different between HBV/HCV coinfection patients and HCV mono-infection patients (OR=1.55, 95% CI: 0.98–2.47, itP/it=0.06; HCV genotype 1: OR=2.4, 95% CI: 1.17–4.91, itP/it=0.19)./p pConclusions/p pTreatment with interferon and ribavirin achieves similar ETVR and SVR in HBV/HCV coinfection and HCV mono-infection. HBV/HCV coinfection patients had distinctively lower end of follow-up serum ALT normalization./p

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关键词：

Coinfection Hepatitis B Hepatitis C Interferon Ribavirin

DOI：

10.1186/1743-422X-9-186

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年份：

2012