Apoptosis control by death and decoy receptors.
摘要：
The death receptors Fas and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis upon engagement by their cognate death ligands. Recently, researchers have discovered several novel homologues of Fas and TNFR1: DR 3, 4, 5, and 6 function as death receptors that signal apoptosis, whereas DcR 1, 2, and 3 act as decoys that compete with specific death receptors for ligand binding. Further, mouse gene knockout studies have enabled researchers to delineate some of the signaling pathways that connect death receptors to the cell's apoptotic machinery.
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关键词：
Animals Mice, Knockout Mice Cytochrome c Group Fatty Acid Desaturases Caspases Protein Kinases DNA-Binding Proteins Membrane Glycoproteins Receptors, Cell Surface
DOI：
10.1016/S0955-0674(99)80034-9
被引量：
年份：
1999
Elsevier
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