Losing your nerves? Maybe it's the antibodies.
摘要：
We propose that the normal immunocompetent B cell repertoire is replete with B cells making antibodies that recognize brain antigens. Although B cells that are reactive with self antigen are normally silenced during B cell maturation, the blood-brain barrier (BBB) prevents many brain antigens from participating in this process. This enables the generation of a B cell repertoire that is sufficiently diverse to cope with numerous environmental challenges. It requires, however, that the integrity of the BBBs is uninterrupted throughout life to protect the brain from antibodies that crossreact with microorganisms and brain antigens. Under conditions of BBB compromise, and during fetal development, we think that these antibodies can alter brain function in otherwise healthy individuals.
展开
关键词：
Animals Humans B-Lymphocytes Brain Receptors, N-Methyl-D-Aspartate Autoantibodies Autoantigens Blood-Brain Barrier
DOI：
10.1038/nri2529
被引量：
年份：
2009
Nature
(全网免费下载)
Springer
Nature
国家科技图书文献中心
(权威机构)
Semantic Scholar
查看更多
掌桥科研
万方医学
dx.doi.org
Ingenta
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
Pubmed Central
(全网免费下载)
Europe PMC
NCBI
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
www.socolar.com
pubfacts.com
readcube.com
mendeley.com
ftp.palgrave-journals.com
scienceopen.com
onAcademic
frontiersin.org
学术范
ajp.psychiatryonline.org
pandasweb.nl
(全网免费下载)
学术范
(全网免费下载)
Nature
(全网免费下载)
Europe PMC
(全网免费下载)
Pubmed Central
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
pandasweb.nl
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
