Additions and Corrections - Synthesis of a Fluorescent Derivative of Amethopterin.
摘要：
Dihydrofolate reductase (EC 1.5.1.3), purified to homogeneity from an amethopterin-resistant subline (R6) of cultured L1210 murine leukemia cells, has been used to study enzyme-substrate and enzyme-inhibitor complexes. NADPH, NADP+acid-modified NADPH (λmax at 265 nm, elevated absorbance at 290 nm), 2′-phosphoadenosine-5′-diphosphate ribose, dihydrofolate, and amethopterin formed binary...
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DOI：
10.1021/jm00246a602
被引量：
年份：
1975
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