摘要：

A thymidine labeling study of cell kinetics of 61in situ breast carcinomas showed relationships between histological characteristics and kinetics. The thymidine labeling index (TLI) was significantly lower in cribriform-papillary intraductal carcinoma (median 30%, geometric mean 18%, mean 83 ± 0.45%) and lobular carcinomain situ (median 43%, geometric mean 12%, mean 63 ± 0.46%) than in comedo intraductal carcinoma (median 4.40%, geometric mean 3.74%, mean 5.15 ± 0.86%). The results for solid intraductal carcinoma, which is a less well defined and more heterogeneous entity, were intermediate (median 2.45%, geometric mean 2.40%, mean 3.32 ± 0.80%). When invasive carcinoma was also available for kinetic study, the TLI ofin situ and invasive components were usually similar (r = 0.66). The data indicate that the TLI usually does not change during the transition fromin situ to invasive carcinoma. Cribriform-papillary intraductal carcinoma is a slowly proliferating entity that giv

展开